Cx36-Mediated Coupling Reduces -Cell Heterogeneity, Confines the Stimulating Glucose Concentration Range, and Affects Insulin Release Kinetics
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چکیده
منابع مشابه
Cx36-Mediated Coupling Reduces -Cell Heterogeneity, Confines the Stimulating Glucose Concentration Range, and Affects Insulin Release Kinetics
We studied the effect of gap junctional coupling on the excitability of -cells in slices of pancreas, which provide a normal environment for islet cells. The electrophysiological properties of -cells from mice (C57Bl/6 background) lacking the gap junction protein connexin36 (Cx36 / ) were compared with heterozygous (Cx36 / ) and wild-type littermates (Cx36 / ) and with frequently used wild-type...
متن کاملCx36-mediated coupling reduces beta-cell heterogeneity, confines the stimulating glucose concentration range, and affects insulin release kinetics.
We studied the effect of gap junctional coupling on the excitability of beta-cells in slices of pancreas, which provide a normal environment for islet cells. The electrophysiological properties of beta-cells from mice (C57Bl/6 background) lacking the gap junction protein connexin36 (Cx36(-/-)) were compared with heterozygous (Cx36(+/-)) and wild-type littermates (Cx36(+/+)) and with frequently ...
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Under appropriate conditions, not only glucose but also glucosamine and galactose can serve as potent stimulants for insulin release from the isolated, perfused rat pancreas. Since galactose and, probably, glucosamine are not metabolized in the islets, and since these three compounds have in all likelihood common sites of action, it is postulated that a glucoreceptor of broad specificity is inv...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2007
ISSN: 0012-1797,1939-327X
DOI: 10.2337/db06-0232